反応 #61728

反応方程式

1-(4-chlorophenyl)ethane-1-one

N,N Dimethylformamide diisopropylacetal

→

title compound

収率 99.0%

(2E)-3-Dimethylamino-1-(4-chlorophenyl)prop-2-en-1-one

収率 99.0%

溶媒

反応条件

後処理

1. 1
   温度to reflux for 16 hours
2. 2
   ろ過The resulting solid was collected via filtration
3. 3
   洗浄washed with hexanes

実験手順

A solution of 1-(4-chlorophenyl)ethane-1-one (35.0 g, 226 mmol) and N,N Dimethylformamide diisopropylacetal (35 mL) was heated to reflux for 16 hours. The reaction mixture was cooled to room temperature and treated with hexanes (50 mL). The resulting solid was collected via filtration and washed with hexanes to provide the title compound as a yellow solid (47.12 g, 99% yield): HPLC Retention Time; 6.45 min (Method B). M+1; 209.

出典