反応 #61688

反応方程式

sodium carbonate

t-butyl 3-(5-iodo-4-(methylamino)-4aH-pyrrolo[2,3-d]pyrimidin-7(7aH)-yl)propanoate

dimethoxy ethyleneglycol

3-Hydroxyphenylboronic acid

→

desired product

tert-Butyl 3-(5-(3-hydroxyphenyl)-4-(methylamino)-4aH-pyrrolo[2,3-d]pyrimidin-7(7aH)-yl)propanoate

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the vessel was purged with argon
3. 3
   温度The reaction was subsequently cooled
4. 4
   ろ過filtered through a bed of celite
5. 5
   その他The filtrate was evaporated in vacuo
6. 6
   その他Silica gel chromatography (ethyl acetate:hexanes) and evaporation in vacuo of the requisite fractions

実験手順

t-butyl 3-(5-iodo-4-(methylamino)-4aH-pyrrolo[2,3-d]pyrimidin-7(7aH)-yl)propanoate (123 mmol) from above was placed in a 25 ml round bottom flask, whereupon 3.1 ml dimethoxy ethyleneglycol was added. 3-Hydroxyphenylboronic acid (492 mmol pre-dissolved in 0.66 ml ethanol) was added at once, and was followed by 0.5 ml saturated aqueous sodium carbonate. Pd0(PPh3)4 (14 mg, 12 umol) was added to the reaction, the vessel was purged with argon, and set to stir at 80 C overnight. The reaction was subsequently cooled, and filtered through a bed of celite. The filtrate was evaporated in vacuo, and the residual material was adhered to silica gel using ethyl acetate as solvent. Silica gel chromatography (ethyl acetate:hexanes) and evaporation in vacuo of the requisite fractions yielded the desired product. MS m/z=369.22.

出典