反応 #61659

反応方程式

5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one

2,3-dichloro-5,6-dicyanobenzoquinone

→

5-acetyl-7-benzyloxy-1H-quinolin-2-one

溶媒

dioxane

反応条件

後処理

1. 1
   温度The mixture is refluxed for 30 minutes
2. 2
   ろ過The solid is filtered off
3. 3
   洗浄washed with dioxane
4. 4
   workup.DISSOLUTIONdissolved in 600 mL dichloromethane/methanol (9:1)
5. 5
   洗浄The solution is washed with sodium hydrogen carbonate solution
6. 6
   乾燥dried with sodium sulphate
7. 7
   その他evaporated down
8. 8
   ろ過filtered
9. 9
   その他dried

実験手順

13.0 g (44 mmol) 5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one are suspended in 130 mL dioxane and combined with 15.0 g (66 mmol) of 2,3-dichloro-5,6-dicyanobenzoquinone. The mixture is refluxed for 30 minutes, cooled to ambient temperature and stirred for a further 2 hours. The solid is filtered off, washed with dioxane and dissolved in 600 mL dichloromethane/methanol (9:1). The solution is washed with sodium hydrogen carbonate solution, dried with sodium sulphate and evaporated down. Then the residue is suspended in methanol, filtered and dried.

出典