反応 #61654

反応方程式

7-acetyl-5-benzyloxy-3H-benzoxazol-2-one

selenium dioxide

charcoal

dioxane

→

5-benzyloxy-7-(2-ethoxy-2-hydroxy-acetyl)-3H-benzoxazol-2-one

溶媒

water

反応条件

後処理

1. 1
   ろ過The solid is filtered off
2. 2
   workup.DISTILLATIONthe solvent is distilled off
3. 3
   温度The mixture is refluxed for 15 minutes
4. 4
   ろ過filtered through activated charcoal
5. 5
   その他The solid precipitated
6. 6
   温度on cooling
7. 7
   ろ過is suction filtered after 3 hours
8. 8
   洗浄washed with ethanol and diethyl ether

実験手順

20 g (71 mmol) 7-acetyl-5-benzyloxy-3H-benzoxazol-2-one and 8 g (72 mmol) selenium dioxide are refluxed for 8 hours in the presence of activated charcoal in 100 mL dioxane and 3.1 mL water. The solid is filtered off, the solvent is distilled off and the residue is combined with 50 mL ethanol. The mixture is refluxed for 15 minutes and then filtered through activated charcoal. The solid precipitated on cooling is suction filtered after 3 hours and washed with ethanol and diethyl ether.

出典