反応 #61525

反応方程式

hydrochloric acid

1-furan-2-yl-ethanone

oxalic acid diethyl ester

KOt-Bu

→

4-Furan-2-yl-2,4-dioxo-butyric acid ethyl ester

溶媒

THF

ethyl acetate

water

THF

反応条件

後処理

1. 1
   その他The organic layer was separated
2. 2
   洗浄washed with 150 ml water
3. 3
   乾燥dried over MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated under reduced pressure
6. 6
   その他to yield a white solid

実験手順

To a solution of 16 g oxalic acid diethyl ester in 350 ml THF, 10.1 g KOt-Bu were added at 0° C. Then 10 g 1-furan-2-yl-ethanone in 50 ml THF were added dropwise. After 1 h the reaction mixture was diluted with 300 ml ethyl acetate and 200 mnl water. This solution was acidified with diluted hydrochloric acid to pH 5. The organic layer was separated, washed with 150 ml water, dried over MgSO4, filtered and concentrated under reduced pressure to yield a white solid.

出典