反応 #61504

反応方程式

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide

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title compound

収率 10.0%

6-[5-(3-[1,3] Dioxan-2-yl-propyl)-4-methyl-4H-[1,2,4] triazol-3-yl]-2-methyl-quinoline

収率 10.0%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which

実験手順

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide (1.28 g, 3.4 mmol) was heated in ethyl acetate (20 ml) for 4 h. The solvent was evaporated and the residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which gave the title compound as a brown solid (109 mg, 10%).

出典