反応 #615008

ord-1495e76500a04efb99f783ec4ce7f812

反応方程式

Nc1nc(F)nc2c1ncn2C1CCCCO1
2-fluoro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine
CCC[C@H](C)N
(2S)-2-pentanamine
→
CCC[C@H](C)Nc1nc(N)c2ncn(C3CCCCO3)c2n1
N2-[(1S)-1-Methylbutyl]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine

反応物

—
Intermediate 70
Nc1nc(F)nc2c1ncn2C1CCCCO1
2-fluoro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine
CCC[C@H](C)N
(2S)-2-pentanamine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared similarly to Intermediate 70 from 2-fluoro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine and (2S)-2-pentanamine.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09346806B2uspto-grants-2016_05