反応 #61450

ord-b8ad5ff2f5294fdfbbf53a8a8b17560a

反応方程式

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isobutoxy-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate
→
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
title compound
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-isobutoxy-5-methanesulfonyl-phenyl) -methanone

反応物

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isobutoxy-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate

試薬

なし

溶媒

CC#N
acetonitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared in analogy to example 1.1(b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride and 2-isobutoxy-5-methanesulfonyl-benzoic acid (example 2.4) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07429585B2uspto-grants-2008_09