反応 #61448

ord-84c047b4b2554a3b8098263785abf800

反応方程式

CC(C)(C)OC(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
4-(6-chloro-quinolin-2-yl)-piperazine-1-carboxylic acid tert.-butyl ester
Cl
hydrochloric acid
→
Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-Chloro-2-piperazin-1-yl-quinoline Hydrochloride

反応物

CC(C)(C)OC(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
4-(6-chloro-quinolin-2-yl)-piperazine-1-carboxylic acid tert.-butyl ester
Cl
hydrochloric acid

試薬

なし

溶媒

C1COCCO1
dioxane

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared in analogy to example 1.6(d) from 4-(6-chloro-quinolin-2-yl)-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07429585B2uspto-grants-2008_09