反応 #61354

ord-912cb49b0d2d41ffa21c8e1383418daa

反応方程式

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl
bicyclononene
CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl
3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester
Clc1cc2c(cc1CNC1CC1)OCO2
(6-chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylamine
→
CC(=O)N1C[C@H]2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)N(Cc3cc4c(cc3Cl)OCO4)C3CC3)[C@@H](C1)N2.O=CO
(rac.)-(1R*,5S*)-3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid (6-chlorobenzo[1,3]-dioxol-5-ylmethyl)cyclopropylamide formate salt

反応物

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl
bicyclononene
CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl
3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester
Clc1cc2c(cc1CNC1CC1)OCO2
(6-chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylamine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他Synthesized

実験手順

Synthesized according to typical procedures H and E from bicyclononene BN10 and (6-chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylamine. LC-MS: Rt=0.90; ES+: 684.19.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07427613B2uspto-grants-2008_09