反応 #612200

反応方程式

2,4-dichloropyrimidine-5-carbonitrile

NH3

→

title compound

収率 56.0%

2-Amino-4-chloropyrimidine-5-carbonitrile

収率 56.0%

溶媒

dioxane

dioxane

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of two isomers
2. 2
   その他were obtained
3. 3
   その他separated by column chromatography
4. 4
   workup.ADDITIONa mixture of hexane/ethyl acetate (from 0% to 45% of ethyl acetate)

実験手順

To a solution of 2,4-dichloropyrimidine-5-carbonitrile (600 mg, 3.45 mmol) in dioxane (20 ml) was added a 0.5M solution of NH3 in dioxane (20 ml, 10 mmol) and the mixture stirred at room temperature for 4 h. A mixture of two isomers were obtained and separated by column chromatography using a mixture of hexane/ethyl acetate (from 0% to 45% of ethyl acetate). The title compound (304 mg, 56% yield) was found to be the less polar isomer.

出典