反応 #61201

ord-152ba462b2be44bf88e9d3b07f2ceb49

反応方程式

C/C=C/C1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccc(O)cc3)[C@H]2SC1
Cefprozil
→
C/C=C/C1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccc(O)cc3)[C@H]2SC1.O
Cefprozil monohydrate

反応物

C/C=C/C1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccc(O)cc3)[C@H]2SC1
Cefprozil

試薬

なし

溶媒

CN(C)C=O
DMF
CN(C)C=O
DMF

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他as obtained
  2. 2
    その他without drying
  3. 3
    ろ過The product is filtered
  4. 4
    その他dried

実験手順

The aqueous solution containing Cefprozil as obtained above is converted to its DMF solvate as per the method disclosed in U.S. Pat. No. 4,694,079. The wet DMF solvate without drying is desolvated by stirring with a mixture of demineralised water (75 ml) and ethyl acetate (45 ml) for 60 minutes. The product is filtered and dried to give Cefprozil monohydrate in the form of an off white to pale yellow crystalline powder.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07427692B2uspto-grants-2008_09