反応 #610242

反応方程式

Cs2CO3

3-chloro-6-(1H-pyrazol-4-yl)isoquinoline

6-oxabicyclo[3.1.0]hexane

→

title compound

収率 50.1%

2-(4-(3-Chloroisoquinolin-6-yl)-1H-pyrazol-1-yl)cyclopentanol

収率 50.1%

溶媒

DMF

反応条件

後処理

1. 1
   温度The reaction was cooled
2. 2
   濃縮concentrated in vacuo
3. 3
   その他purified
4. 4
   洗浄eluting with 50-75% EtOAc/cyclohexane

実験手順

A mixture of Cs2CO3 (45.4 mg, 0.139 mmol), 3-chloro-6-(1H-pyrazol-4-yl)isoquinoline (16 mg, 0.070 mmol) and 6-oxabicyclo[3.1.0]hexane (Preparation 37, 23.4 mg, 0.279 mmol) in DMF (3 mL) was stirred at 120° C. under microwave irradiation for 60 minutes. The reaction was cooled, concentrated in vacuo and purified using Biotage silica gel column chromatography eluting with 50-75% EtOAc/cyclohexane to give the title compound as white solid (11 mg, 50%).

出典