反応 #61022

ord-cee4307d238e4013ae44af9eac6a34e4

反応方程式

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
CNS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-methylsulfamoyl-benzoic acid
OCC1CCNC1
rac-pyrrolidin-3-yl-methanol
→
CNS(=O)(=O)c1ccc(N2CCC(CO)C2)c(C(=O)O)c1
title compound
収率 25.0%
CNS(=O)(=O)c1ccc(N2CCC(CO)C2)c(C(=O)O)c1
rac-2-(3-Hydroxymethyl-pyrrolidin-1-yl)-5-methylsulfamoyl-benzoic acid
収率 25.0%

反応物

—
313.0
CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
CNS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-methylsulfamoyl-benzoic acid
OCC1CCNC1
rac-pyrrolidin-3-yl-methanol

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他obtained in 25% yield

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-methylsulfamoyl-benzoic acid and rac-pyrrolidin-3-yl-methanol and obtained in 25% yield. MS (m/e): 313.0 MH− (100%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07427612B2uspto-grants-2008_09