反応 #60977

ord-fb34a088c9ed487683f859ea7c406baf

反応方程式

CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone
CN(C)S(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-dimethylsulfamoyl-benzoic acid
→
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(=O)(=O)N(C)C)ccc3Cl)CC2)c(F)c1
title compound
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(=O)(=O)N(C)C)ccc3Cl)CC2)c(F)c1
3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N,N-dimethyl-benzenesulfonamide

反応物

CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone
CN(C)S(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-dimethylsulfamoyl-benzoic acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared according to the procedure described for example K/step2 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone and 2-Chloro-5-dimethylsulfamoyl-benzoic acid (CAS: 37088-27-0; BE 620741) (64%, light yellow foam, MS (m/e): 468.1 (M+H+, 100%)

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07427612B2uspto-grants-2008_09