反応 #60969

ord-11e7349391db427aa8f0b88c2e719f51

反応方程式

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
O=C(O)c1cc(S(=O)(=O)NCC2CC2)ccc1Cl
2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid
C1COCCN1
morpholine
→
O=C(O)c1cc(S(=O)(=O)NCC2CC2)ccc1N1CCOCC1
title compound
収率 33.0%
O=C(O)c1cc(S(=O)(=O)NCC2CC2)ccc1N1CCOCC1
5-(Cyclopropylmethyl-sulfamoyl)-2-morpholin-4-yl-benzoic acid
収率 33.0%

反応物

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
O=C(O)c1cc(S(=O)(=O)NCC2CC2)ccc1Cl
2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid
C1COCCN1
morpholine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他obtained in 33% yield

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid and morpholine and obtained in 33% yield. MS (m/e): 339.2 (MH−, 100%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07427612B2uspto-grants-2008_09