反応 #60968

ord-3da9b9c888d1434e8a16c3791cde1596

反応方程式

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
CC(C)NS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-isopropylsulfamoyl-benzoic acid
C1COCCN1
morpholine
→
CC(C)NS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)O)c1
title compound
収率 38.0%
CC(C)NS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)O)c1
5-Isopropylsulfamoyl-2-morpholin-4-yl-benzoic acid
収率 38.0%

反応物

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
CC(C)NS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-isopropylsulfamoyl-benzoic acid
C1COCCN1
morpholine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他obtained in 38% yield

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-isopropylsulfamoyl-benzoic acid and morpholine and obtained in 38% yield. MS (m/e): 327.2 (MH−, 100%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07427612B2uspto-grants-2008_09