反応 #60948

反応方程式

2-Chloro-5-sulfino-benzoic acid

Methylamine

→

title compound

収率 72.5%

2-Chloro-5-methylsulfamoyl-benzoic acid

収率 72.5%

溶媒

dioxane

反応条件

後処理

1. 1
   その他After evaporation of the volatiles 15 ml 5N HCl
2. 2
   workup.ADDITIONwas added
3. 3
   抽出the mixture was extracted 3× with ethylacetate
4. 4
   その他The solvent was removed under vacuum

実験手順

A mixture of 1 g (4 mmol) 2-Chloro-5-sulfino-benzoic acid and 0.62 g (20 mmol) Methylamine in 10 ml dioxane was stirred for 3 h at room temperature. After evaporation of the volatiles 15 ml 5N HCl was added and the mixture was extracted 3× with ethylacetate. The solvent was removed under vacuum to yield 0.724 g (72%) of the title compound as amorphous white solid. MS (m/e): 248.1 (MH−, 100%).

出典