反応 #60824

反応方程式

Diisopropyl azodicarboxylate

8-(1-methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine

8-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine

cyclohexanol

triphenylphosphine

→

title compound

収率 11.0%

9-Cyclohexyl-8-(1-methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine

収率 11.0%

溶媒

THF

反応条件

後処理

1. 1
   温度was heated at 40° C. for 48 hours
2. 2
   workup.WAITat 55° C. for 24 hours
3. 3
   その他The solvent was then evaporated in vacuo
4. 4
   その他to give a brown oil
5. 5
   その他Purification by preparative LCMS

実験手順

Diisopropyl azodicarboxylate (0.1 mL) was added to a solution of 8-(1-methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine (Example 3) (75 mg), cyclohexanol (0.07 mL) and triphenylphosphine (0.14 g) in THF (4 mL) under an inert atmosphere. After stirring at ambient temperature for 48 hours the reaction mixture was heated at 40° C. for 48 hours and then at 55° C. for 24 hours. The solvent was then evaporated in vacuo to give a brown oil. Purification by preparative LCMS gave the title compound as a white solid (11 mg, 11%);

出典