反応 #60812
ord-69b889d0d7d7475b9bcc72634c317de5
反応方程式
6-methyl-4-chlorofuro[2,3-d]pyrimidine
sodium thiomethoxide
→
title compound
収率 90.0%
6-Methyl-4-(methylthio)furo[2,3-d]pyrimidine
収率 90.0%
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1ろ過The mixture was filtered
- 2洗浄the solids washed with acetonitrile
- 3その他Evaporation of the solvent
実験手順
A solution of 6-methyl-4-chlorofuro[2,3-d]pyrimidine (U.S. Pat. No. 3,577,420, example IG) (219 mg) in acetonitrile (25 mL) was heated under reflux with sodium thiomethoxide (190 mg) for 16 hours. The mixture was filtered and the solids washed with acetonitrile. Evaporation of the solvent afforded the title compound as a white solid (230 mg, 90%);