反応 #60793

反応方程式

DIPEA

methyl [(6chloro-5-formylpyrimidin-4-yl)thio]acetate

intermediate 9

methyl [(6chloro-5-formylpyrimidin-4-yl)thio]acetate

→

title compound

収率 53.9%

Methyl 4-chlorothieno[2,3-d]pyrimidine-6-carboxylate

収率 53.9%

溶媒

cyclohexanol

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the product purified by flash chromatography on silica eluting with hexane:diethyl ether (4:1)

実験手順

DIPEA (2.1 mL) was added to methyl [(6chloro-5-formylpyrimidin-4-yl)thio]acetate (intermediate 9) (2.9 g) in cyclohexanol (50 mL) under an inert atmosphere. The reaction mixture was heated at 120° C. for 90 minutes. The solvent was evaporated and the product purified by flash chromatography on silica eluting with hexane:diethyl ether (4:1) to afford the title compound as a pale yellow solid (1.45 g, 53%);

出典