反応 #607493

反応方程式

4-bromo-2-fluorobenzoic acid

oxalyl chloride

DMF

→

4-bromo-2-fluorobenzoyl chloride

収率 100.1%

溶媒

DCM

反応条件

後処理

1. 1
   濃縮The mixture was concentrated under reduced pressure

実験手順

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

出典