反応 #607487

反応方程式

137g

3-(1,3-dioxoisoindolin-2-yl)propanoic acid

oxalyl chloride

DMF

→

3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

収率 92.5%

溶媒

DCM

反応条件

後処理

1. 1
   その他Upon reaction completion
2. 2
   濃縮the mixture was concentrated

実験手順

To a solution of 137g (20.0 g, 91 mmol) in DCM (250 mL) were added oxalyl chloride (13.8 g, 109 mmol) and DMF (0.1 mL). See FIG. 2. The mixture was stirred at RT for 4 h. Upon reaction completion, the mixture was concentrated to give 3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 137h (20.0 g, 92%) as a white solid.

出典