反応 #607486

反応方程式

isobenzofuran-1,3-dione

3-aminopropanoic acid

→

3-(1,3-dioxoisoindolin-2-yl)propanoic acid

収率 69.0%

溶媒

water

反応条件

後処理

1. 1
   その他Upon reaction completion
2. 2
   抽出extracted with DCM (100 mL×3)
3. 3
   乾燥The combined organic layers were dried over anhydrous sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated under reduced pressure

実験手順

A mixture of isobenzofuran-1,3-dione (20 g, 135 mmol) and 3-aminopropanoic acid (12 g, 135 mmol) was stirred at 170° C. for 6 h. See FIG. 2. Upon reaction completion, the mixture was diluted with water and extracted with DCM (100 mL×3). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give 3-(1,3-dioxoisoindolin-2-yl)propanoic acid 137g (20 g, 69%) as a white solid.

出典