反応 #607482

反応方程式

123b

6-tert-butyl-2-(4-(5-(diphenylmethyleneamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-(hydroxymethyl)pyridin-2-yl)-8-fluorophthalazin-1(2H)-one

→

123d

収率 50.0%

2-(4-(5-amino-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-(hydroxymethyl)-pyridin-2-yl)-6-tert-butyl-8-fluorophthalazin-1(2H)-one

収率 50.0%

溶媒

HCl dioxane

反応条件

後処理

1. 1
   その他The mixture was evaporated in vacuo
2. 2
   その他the residue was purified by reverse-phase prep-HPLC

実験手順

A mixture of 123b (1.6 g, 2.6 mmol) in HCl/dioxane (4M, 10 mL) was stirred at 25° C. for 1 h. The mixture was evaporated in vacuo and the residue was purified by reverse-phase prep-HPLC to afford 123d (580 mg, 50%) as a pale yellow solid. MS-ESI: [M+H]+ 450.1. 1H NMR (500 MHz, DMSO-d6) δ 8.53-8.52 (m, 2H), 7.90 (d, J=1.0 Hz, 1H), 7.79-7.76 (m, 1H), 7.45 (d, J=5.0 Hz, 1H), 7.24 (d, J=2.5 Hz, 1H), 6.65 (d, J=2.0 Hz, 1H), 5.33 (s, 2H), 4.95-4.93 (m, 1H), 4.39 (s, 2H), 3.52 (s, 3H), 1.38 (s, 9H).

出典