反応 #607446

反応方程式

2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanone

sodium borohydride

NH4Cl

→

2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanol

収率 105.1%

溶媒

methanol

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGwith additional stirring for 10 min
3. 3
   抽出The later was extracted 3 times with 20 mL of EtOAc
4. 4
   洗浄washed with 10 mL of brine
5. 5
   乾燥dried over Na2SO4
6. 6
   ろ過filtered
7. 7
   その他The solvent was removed under reduced pressure

実験手順

In a 50 mL two-neck flask, 2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanone (2.0 g, 8.3 mmol) was dissolved in methanol (8 mL) and sodium borohydride (0.31 g, 8.3 mmol) was added carefully in portions with ice-bath cooling. The resultant colourless solution was stirred at RT for 2 hours and monitored by TLC. Upon the disappearance of all starting material, 5 mL of an aqueous saturated NH4Cl solution was slowly added to the reaction mixture with additional stirring for 10 min. The later was extracted 3 times with 20 mL of EtOAc and the organic fractions were combined and washed with 10 mL of brine, dried over Na2SO4, and filtered. The solvent was removed under reduced pressure to give 2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanol (2.13 g, quantitative) as a colourless oil which was used with no further purification.

出典