反応 #607442

反応方程式

3-bromo-2-(cis-4-isopropylcyclohexoxy)-6-methyl-5-nitro-pyridine

ammonium chloride

→

title compound

収率 101.5%

5-bromo-6-(cis-4-isopropylcyclohexoxy)-2-methyl-pyridin-3-amine

収率 101.5%

溶媒

EtOH H2O

反応条件

後処理

1. 1
   温度under heating to reflux
2. 2
   その他was consumed at this point in time
3. 3
   ろ過filtered through a pad of celite
4. 4
   濃縮The resulting filtrate was concentrated in vacuo
5. 5
   その他the residue partitioned between a 2 molar aqueous NaOH solution (100 mL) and ethyl acetate (150 mL)
6. 6
   その他After phase separation
7. 7
   抽出the aqueous phase was extracted once more with ethyl acetate (2×100 mL)
8. 8
   洗浄The organic layer was washed with brine (400 mL)
9. 9
   乾燥dried over anhydrous Na2SO4
10. 10
    ろ過filtered
11. 11
    その他The solvent was removed in vacuo

実験手順

To a stirred solution of 3-bromo-2-(cis-4-isopropylcyclohexoxy)-6-methyl-5-nitro-pyridine (22.59 g, 63.24 mmol) in EtOH/H2O (600 mL/150 mL, 4/1 v/v), ammonium chloride (3.45 g, 63.24 mmol, 1.0 eq) and iron powder (14.27 g, 253.0 mmol, 4 eq) were added at room temperature under inert atmosphere (Ar). The reaction mixture was stirred for 3 h under heating to reflux. As TLC indicated that the starting material was consumed at this point in time, the reaction mixture was cooled to room temperature and filtered through a pad of celite. The resulting filtrate was concentrated in vacuo and the residue partitioned between a 2 molar aqueous NaOH solution (100 mL) and ethyl acetate (150 mL). After phase separation, the aqueous phase was extracted once more with ethyl acetate (2×100 mL). The organic layer was washed with brine (400 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed in vacuo to afford the title compound (21.01 g, 101%) in the form of an oil.

出典