反応 #6071

反応方程式

dimethyl maleate

phenyl vinyl sulfide

ethylaluminum dichloride

hexane

→

title compound

Dimethyl 3-phenylthiocyclobutane-1,2-dicarboxylate

溶媒

1,2-dichloroethane

methylene chloride

反応条件

後処理

1. 1
   洗浄The methylene chloride solution was washed three times with saturated aqueous ammonium chloride
2. 2
   乾燥once with brine, dried over anhydrous sodium sulfate
3. 3
   ろ過filtered
4. 4
   濃縮concentrated

実験手順

To a solution of dimethyl maleate (0.50 mL, 4 mmol) and phenyl vinyl sulfide (0.52 mL, 4 mmol) in 17 mL of 1,2-dichloroethane under nitrogen atmosphere, was added 1 equivalent (4 mL of a 1 M solution in hexane) of ethylaluminum dichloride. The resultant solution was heated at 85° C. for 18 h and then diluted with 75 mL of methylene chloride. The methylene chloride solution was washed three times with saturated aqueous ammonium chloride and once with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 0.98 g of the title compound; EI-MS, m/e (rel intensity): 280 (M+, 14), 136 (100).

出典