反応 #60704

反応方程式

water

3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

potassium carbonate

2-bromo-1-fluoroethane

→

title compound

収率 32.9%

3-Chloro-N-[1-(2-chlorophenyl)-2-[1-(2-fluoroethyl)-piperidin-4-ylmethoxy]ethyl]-1H-indole-6-carboxamide

収率 32.9%

溶媒

DMSO

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the resulting precipitate was isolated by filtration
3. 3
   その他Purification of the filtrate (SiO2: EtOAc)

実験手順

To a solution of 3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.3 mmol) in 6 mL of DMSO was added potassium carbonate (716 mg, 5.2 mmol) and 2-bromo-1-fluoroethane (0.10 mL, 1.1 mmol). The reaction was allowed to stir at room temperature overnight after which time water was added and the resulting precipitate was isolated by filtration. Purification of the filtrate (SiO2: EtOAc) provided 178 mg (28%) of the title compound.

出典