反応 #60703

反応方程式

3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

acetaldehyde

→

3-Chloro-N-[1-(2-chlorophenyl)-2-(1-ethylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide

反応条件

後処理

1. 1
   その他afforded
2. 2
   その他after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine) and recrystallization (acetonitrile), 275 mg (43%) of the title compound

実験手順

Using alkylation method A, 3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.3 mmol) and acetaldehyde (0.4 mL, 6.7 mmol) afforded, after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine) and recrystallization (acetonitrile), 275 mg (43%) of the title compound.

出典