反応 #60702

反応方程式

3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

paraformaldehyde

→

3-Chloro-N-[1-(2-chlorophenyl)-2-(1-methylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide

反応条件

後処理

1. 1
   その他afforded
2. 2
   その他after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine), 175 mg (57%) of the title compound

実験手順

Using alkylation method B, 3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (300 mg, 0.67 mmol) and paraformaldehyde (201 mg, 6.7 mmol) afforded, after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine), 175 mg (57%) of the title compound.

出典