反応 #60374

反応方程式

(5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-methanol

(BOC)2O

→

final product

(6-Hydroxymethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamic acid tert-butyl Ester

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他Reaction mixture
2. 2
   その他was quenched with sat. NH4Cl
3. 3
   その他the organic layer was isolated
4. 4
   洗浄washed with water, brine
5. 5
   乾燥dried over MgSO4
6. 6
   その他evaporated in vacuo

実験手順

To a solution of (5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-methanol (2.0 g, 11.28 mmol) in CH2Cl2 (20 mL) was added (BOC)2O (2.7 g, 12.41 mmol). The resulting mixture was stirred at RT under N2 gas for 2 h. Reaction mixture was quenched with sat. NH4Cl, the organic layer was isolated and washed with water, brine, dried over MgSO4 and evaporated in vacuo to give the final product. MS m/z: 278.12 (M+H). Calc'd. for C16H23NO3-277.36.

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