反応 #60363

ord-bf81950fa04d4f2088e42476cf0f6e96

反応方程式

O=C(O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1
3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionic acid
COC(=O)c1ccc2c(c1)N(C)S(=O)(=O)CC2N
4-amino-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazine-7-carboxylic acid methyl ester
→
COC(=O)c1ccc2c(c1)N(C)S(=O)(=O)CC2NC(=O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1
title compound
COC(=O)c1ccc2c(c1)N(C)S(=O)(=O)CC2NC(=O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1
4-(3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionylamino)-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazine-7-carboxylic acid methyl ester

反応物

O=C(O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1
3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionic acid
COC(=O)c1ccc2c(c1)N(C)S(=O)(=O)CC2N
4-amino-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazine-7-carboxylic acid methyl ester

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared from 3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionic acid Example 1, Step H and 4-amino-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazine-7-carboxylic acid methyl ester (Step B) similar to that described in Example 1, Step F. MS (+APCI, m/z): 608 (M+H)+.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07425631B2uspto-grants-2008_09