反応 #60342

反応方程式

tert-Butyl-chloro-dimethyl-silane

4-chromanol

N-methylmorpholine

imidazole

→

title compound

tert-butyl-(chroman-4-yloxy)-dimethyl-silane

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   洗浄washed with dilute HCl and H2O
2. 2
   乾燥dried over MgSO4
3. 3
   ろ過filtered
4. 4
   濃縮concentrated in vacuo

実験手順

tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.

出典