反応 #6026

反応方程式

product

methyl 4-hydroxy-3,5-di(2-propen-1-yl)benzoate

tert-butyldimethylsilyl chloride

triethylamine

→

title compound

収率 97.2%

methyl 4-tert-butyldimethylsilyloxy-3,5-di(2-propen-1-yl)benzoate

収率 97.2%

溶媒

dichloromethane

反応条件

後処理

1. 1
   濃縮The mixture was concentrated
2. 2
   その他flash chromatographed with 5%

実験手順

The product of Step B (3.1 g, 13.36 mmol) was treated with tert-butyldimethylsilyl chloride (2.22 g, 1.1 equiv), triethylamine (3 mL) and DMAP (0.1 equiv) in dichloromethane overnight. The mixture was concentrated and flash chromatographed with 5% and then 10% ethyl acetate in hexane to furnish 4.5 g (97%) of the title compound.

出典