反応 #60253

反応方程式

(2-bromo-ethoxy)-carbamic acid tert-butyl ester

morpholine

→

desired product

収率 46.0%

(2-Morpholin-4-yl-ethoxy)-carbamic acid tert-butyl ester

収率 46.0%

溶媒

EtOAc

DMF

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   乾燥The organic layer is dried over MgSO4
3. 3
   ろ過filtered
4. 4
   濃縮concentrated
5. 5
   その他purified by flash chromatography (2% MeOH in CH2Cl2)

実験手順

To a solution of (2-bromo-ethoxy)-carbamic acid tert-butyl ester (252 mg, 1.05 mmol) in DMF (2 mL) at room temperature is added morpholine (0.14 mL, 1.6 mmol). The reaction mixture is stirred for 7 hours at 50° C. The reaction mixture is diluted with EtOAc, and washed with water. The organic layer is dried over MgSO4, filtered, concentrated, and purified by flash chromatography (2% MeOH in CH2Cl2) to give the desired product (118 mg, 46%): MS APCI (+) m/z 247 detected.

出典