反応 #6024

反応方程式

methyl 4-hydroxy-3-propenylbenzoate

potassium carbonate

allyl bromide

→

title compound

収率 87.0%

methyl 3-(2-propen-1-yl)-4-(2-propen-1-yloxy)benzoate

収率 87.0%

溶媒

acetone

反応条件

後処理

1. 1
   ろ過The mixture was filtered through Celite
2. 2
   洗浄the filter cake was washed with more acetone and dichloromethane
3. 3
   その他After removing the solvents
4. 4
   workup.DISTILLATIONthe resulting oil was distilled under high vacuum

実験手順

A solution of 3.04 g (15.8 mmol) of methyl 4-hydroxy-3-propenylbenzoate (Example 42, Step B) was refluxed with anhydrous potassium carbonate (4.37 g, 2 equiv) and allyl bromide (3.5 mL, 2.5 equiv) in acetone overnight. The mixture was filtered through Celite and the filter cake was washed with more acetone and dichloromethane. After removing the solvents, the resulting oil was distilled under high vacuum to give 3.2 g (87%) of the title compound.

出典