反応 #601469

反応方程式

Sodium iodide

chloromethyl arachidate

→

desired product

収率 71.0%

Iodomethyl Arachidate

収率 71.0%

溶媒

aluminum

acetonitrile

反応条件

後処理

1. 1
   その他The reaction mixture was partitioned between dichloromethane and water
2. 2
   抽出The aqueous layer was extracted with dichloromethane
3. 3
   洗浄The combined organic extracts were washed with aqueous saturated NaHCO3, aqueous sodium sulfite (10% solution), and brine
4. 4
   乾燥dried with sodium sulphate
5. 5
   濃縮concentrated in vacuo

実験手順

Sodium iodide (8.31 g, 0.0555 mol) was added to a solution of chloromethyl arachidate (6.7 g, 0.0185 mol) in acetonitrile (67 ml) at 25° C. The flask was covered in aluminum foil to protect from light and stirred at 25° C. for 16 hours. The reaction mixture was partitioned between dichloromethane and water. The aqueous layer was extracted with dichloromethane. The combined organic extracts were washed with aqueous saturated NaHCO3, aqueous sodium sulfite (10% solution), and brine, then dried with sodium sulphate and concentrated in vacuo to provide the desired product (5.9 g, 71% yield) as a white solid which was not purified any further.

出典