反応 #60025

反応方程式

Methyl 4-formylbenzoate

potassium carbonate

p-toluenesulfonylmethyl isocyanide

→

methyl 4-(1,3-oxazol-5-yl)benzoate

収率 79.9%

溶媒

methanol

反応条件

後処理

1. 1
   濃縮was then concentrated to dryness in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
3. 3
   洗浄washed twice with water
4. 4
   その他dried
5. 5
   濃縮concentrated in vacuo

実験手順

Methyl 4-formylbenzoate (Aldrich Chemical Co., St. Louis, Mo.) (5.0 g, 30.5 mmol), anhydrous potassium carbonate (4.55 g, 33 mmol) and p-toluenesulfonylmethyl isocyanide (TOSMIC, Aldrich Chemical Co.) (6.83 g, 30.5 mmol) were refluxed in methanol (100 ml) for 3.5 hours The mixture was then concentrated to dryness in vacuo. The residue was dissolved in ethyl acetate, washed twice with water, dried and concentrated in vacuo to give methyl 4-(1,3-oxazol-5-yl)benzoate as a beige solid (4.95 g).

出典