反応 #59941

反応方程式

( 5h )

2-(((3-methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

4-chloro-2,3-dimethylpyridine 1-oxide

2-(2-(methoxymethyl)-1,3-dioxolan-2-yl)ethanol

→

title compound

収率 3.9%

2-(((4-(2-(2-(methoxymethyl)-1,3-dioxolan-2-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

収率 3.9%

反応条件

実験手順

The same procedure as in the steps (5d) to (5h) of Example 5 was repeated using 4-chloro-2,3-dimethylpyridine 1-oxide and 2-(2-(methoxymethyl)-1,3-dioxolan-2-yl)ethanol to obtain the title compound (312 mg, 5 steps 3.9%) as a light yellow foam.

出典