反応 #5986

反応方程式

methyl 2-chloro-cis-5a,6,7,8, 9,9a-hexahydrodibenzofuran-4-carboxylate

→

2-chloro-cis-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylic acid

溶媒

water

sodium hydroxide

dioxane

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   抽出extracted with ethyl acetate
3. 3
   乾燥dried over magnesium sulfate
4. 4
   その他evaporated to dryness
5. 5
   その他to obtain an oily product which
6. 6
   その他crystallizes

実験手順

A mixture of 2 g methyl 2-chloro-cis-5a,6,7,8, 9,9a-hexahydrodibenzofuran-4-carboxylate in 30 ml 1N sodium hydroxide and 5 ml dioxane is stirred at 60° C. for 5 hours. This is then diluted with water, filtered, acidified with acetic acid, extracted with ethyl acetate, dried over magnesium sulfate and evaporated to dryness to obtain an oily product which crystallizes on standing. This is recrystallyzed to obtain 2-chloro-cis-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylic acid. (M.P. 132°-4° C.)

出典