反応 #5985

反応方程式

methyl 3-(3-cyclohexenyl)-5chlorosalicylate

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METHYL 2-CHLORO-TRANS-5a,6,7,8,9,9a-HEXAHYDRODIBENZOFURAN-4-CARBOXYLATE

溶媒

trifluoroacetic acid

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hexanes

反応条件

後処理

1. 1
   その他The cooled reaction mixture
2. 2
   洗浄washed three times with water
3. 3
   その他dried
4. 4
   その他evaporated to dryness
5. 5
   その他The residue is purified with flash chromatography
6. 6
   その他to give four fractions

実験手順

A mixture of 9 g of methyl 3-(3-cyclohexenyl)-5chlorosalicylate and 20 ml trifluoroacetic acid is heated at 70° C. overnight. The cooled reaction mixture is diluted with hexanes, washed three times with water, dried and evaporated to dryness. The residue is purified with flash chromatography using 10% ethyl acetate/hexane to give four fractions

出典