反応 #598373

反応方程式

Water

4-amino-piperidine-1-carboxylic acid tert-butyl ester

4-fluoro-2-trifluoromethyl-benzonitrile

potassium carbonate

→

desired compound

収率 68.0%

4-(4-cyano-3-trifluoromethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

収率 68.0%

溶媒

dimethylsulfoxide

反応条件

後処理

1. 1
   その他the precipitate formed
2. 2
   その他is collected

実験手順

A mixture of 4-amino-piperidine-1-carboxylic acid tert-butyl ester (200 mg; 1.0 mmol), 4-fluoro-2-trifluoromethyl-benzonitrile (208 mg; 1.01 mmol) and potassium carbonate (276 mg; 2.0 mmol) in dimethylsulfoxide (3 mL) is heated to 100° C. over night. Water is then added and the precipitate formed is collected to afford the desired compound (250 mg; 0.68 mmol).

出典