反応 #59836

反応方程式

trifluoromethane sulfonic acid-6-bromo-2-naphthyl ester

isopropylmagnesiumbromide

lithium bromide

→

aimed compound

収率 33.0%

2-bromo-6-isopropylnaphthalene

収率 33.0%

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   その他equipped
2. 2
   温度with cooling pipe
3. 3
   その他After the reaction terminated
4. 4
   workup.ADDITIONadding dilute hydrochloric acid in an amount of 100 milliliter into the reacted solution
5. 5
   その他an organic layer was separated
6. 6
   洗浄washed with the use of sodium bicarbonate solution and sodium chloride solution
7. 7
   乾燥by drying with the use of magnesium sulfate
8. 8
   その他After removing the solvent
9. 9
   workup.DISTILLATIONby distillation
10. 10
    その他by means of a rotary evaporator

実験手順

Under an atmospheric argon gas flow, trifluoromethane sulfonic acid-6-bromo-2-naphthyl ester in an amount of 32 g (90 mmol), dichloro(diphenylphosphinoferrocene)palladium in an amount of 3.6 g (5% by mol), lithium bromide in an amount of 7.8 g (90 mmol) and desiccated tetrahydrofuran in an amount of 100 milliliter were placed into three necked-flask equipped with cooling pipe and having a capacity of 500 milliliter, and then, the resultant solution was cooled down to −20° C. After slowly dripping isopropylmagnesiumbromide in an amount of 90 milliliter (90 mmol, 1 mol/liter (tetrahydrofuran)) into the flask, the resultant solution was stirred under heating at the temperature of 80° C. for 4 hours. After the reaction terminated, adding dilute hydrochloric acid in an amount of 100 milliliter into the reacted solution, an organic layer was separated and washed with the use of sodium bicarbonate solution and sodium chloride solution, followed by drying with the use of magnesium sulfate. After removing the solvent by distillation by means of a rotary evaporator, the resultant crude product was refined by means of column chromatography (silicagel, hexane/dichloromethane=90/10), and as a result, 9.4 g of aimed compound (white crystal) was obtained (yield: 33%).

出典