反応 #59793

反応方程式

4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-1H-imidazole

4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-1H -imidazole

diisopropylethylamine

dimethylformamide

dimethylformamide

2-Chloro-N,N-dimethyl-acetamide

→

2-{4-[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-methyl-acetamide

溶媒

methylene chloride

water

反応条件

後処理

1. 1
   その他The vial was capped
2. 2
   濃縮concentrated in vacuo

実験手順

2-Chloro-N,N-dimethyl-acetamide (0.0194 mmol) in dimethylformamide (0.25 mL) was pipeted into a 4 mL vial containing a solution of 4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-1H-imidazole (0.0169 mmol, example 1) and diisopropylethylamine (0.0194 mmol) in 0.25 mL of dimethylformamide. The vial was capped and heated to 65° C. for 2 d. The reaction was diluted with 1.5 mL of methylene chloride and 0.5 mL of water. The vial was agitated and centrifuged. The organic layer was transferred to a 4 mL vial and concentrated in vacuo to give 2-{4-[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-methyl-acetamide. LR-MS: 663 [(M+H)+].

出典