反応 #59791

反応方程式

Hydrochloric acid

[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-tert-butyloxycarbonylpiperazin-1-yl]-methanone

→

[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-(piperazin-1-yl)-methanone hydrochloride

収率 98.0%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他Evaporation of the solvent

実験手順

Hydrochloric acid (10 mL, 40 mmol, 4 M in 1,4-dioxane) was added to a cooled (0° C.) solution of [4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-tert-butyloxycarbonylpiperazin-1-yl]-methanone in 1,4-dioxane (10 mL). The mixture was stirred at room temperature overnight. Evaporation of the solvent gave [4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-(piperazin-1-yl)-methanone hydrochloride as an off-white solid (1.10 g, 98% yield).

出典