反応 #59780

反応方程式

2-(5-carbamimidoyl-2-benzyloxy-phenyl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide-hydrochloride

triethylamine

4-nitrophenylbenzoate

→

2-[5-(N-benzoyl-carbamimidoyl)-2-benzyloxy-phenyl]-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度The reaction mixture is refluxed for 4 hours
2. 2
   workup.ADDITIONAfter the addition of 100 ml of saline solution the aqueous phase
3. 3
   抽出is extracted 3× with methylene chloride
4. 4
   乾燥The combined organic phases are dried over sodium sulphate
5. 5
   濃縮concentrated by evaporation

実験手順

350 mg (0.69 mmol) of 2-(5-carbamimidoyl-2-benzyloxy-phenyl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide-hydrochloride are suspended in 40 ml of methylene chloride and combined with 1.0 ml of triethylamine and 300 mg (1.3 mmol) of 4-nitrophenylbenzoate. The reaction mixture is refluxed for 4 hours. After the addition of 100 ml of saline solution the aqueous phase is extracted 3× with methylene chloride. The combined organic phases are dried over sodium sulphate and concentrated by evaporation.

出典