反応 #5978

反応方程式

methyl 3-(3-cyclohexenyl)-4-acetylamino-5-chlorosalicylate

trifluoroacetic acid

→

methyl 1-acetylamino-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylate

反応条件

後処理

1. 1
   その他The acid is removed under vacuum
2. 2
   workup.ADDITIONthe residue diluted with ether
3. 3
   洗浄washed with sodium bicarbonate
4. 4
   乾燥water, dried
5. 5
   その他evaporated to dryness

実験手順

A mixture of 1.2 g of methyl 3-(3-cyclohexenyl)-4-acetylamino-5-chlorosalicylate and 5 ml trifluoroacetic acid are stirred at room temperature overnight. The acid is removed under vacuum and the residue diluted with ether, washed with sodium bicarbonate, then water, dried and evaporated to dryness to give crude methyl 1-acetylamino-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylate. This product is purified by flash chromatography using 10% ethyl acetate/hexane to give pure product.

出典