反応 #59677

反応方程式

Thionyl chloride

3-iodo-4-methylbenzoic acid

→

desired product

3-Iodo-4methylbenzoyl chloride

溶媒

chloroform

反応条件

後処理

1. 1
   その他The solvent was removed in vacuo and excess thionyl chloride
2. 2
   その他removed
3. 3
   その他by azeotroping with toluene (3×30 ml)

実験手順

Thionyl chloride (8.2 ml, 112.5 mmol) was added to a mixture of 3-iodo-4-methylbenzoic acid (18.5 g, 75 mmol) in chloroform (100 ml) and heated at 61° C. for 16 hours. The solvent was removed in vacuo and excess thionyl chloride removed by azeotroping with toluene (3×30 ml). The desired product was formed as a beige solid (19.5 g 93%) and used in subsequent reactions without further purification.

出典