反応 #595684

反応方程式

4-Fluorobenzyl bromide

potassium carbonate

N-ethylcarbamate 5-hydroxy-6-chloro-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

→

subtitle compound

N-Ethylcarbamate 5-(4-fluorobenzyloxy)-6-chloro-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度The reaction was cooled to room temperature
2. 2
   濃縮concentrated by rotary evaporation
3. 3
   抽出The product was extracted with EtOAc (3×10 mL)
4. 4
   乾燥The combined organic extracts were dried over MgSO4
5. 5
   濃縮concentrated

実験手順

4-Fluorobenzyl bromide (23 μL, 0.19 mmol) and potassium carbonate (100 mg, 0.78 mmol) were added to a solution of N-ethylcarbamate-5-hydroxy-6-chloro-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole (from Example 5, Step A) (46 mg, 0.16 mmol) in acetonitrile (3 mL), and stirred overnight at 80° C. The reaction was cooled to room temperature, concentrated by rotary evaporation and taken up in H2O (5 mL). The product was extracted with EtOAc (3×10 mL). The combined organic extracts were dried over MgSO4 and concentrated to afford the subtitle compound, which was used without further purification. MS calculated for C22H23ClFNO3+H: 404, observed: 404.

出典